SPRAVATO® TREATMENT · ALEXANDRIA, VIRGINIA
SPRAVATO® Treatment for Depression
A different approach for adults living with certain forms of depression when traditional treatment hasn't provided enough relief.
Z&Z Wellness provides medically supervised SPRAVATO® (esketamine) treatment in a supportive clinical setting, with individualized evaluation, required monitoring, and ongoing care throughout your treatment.
A DIFFERENT APPROACH TO DEPRESSION
What Is SPRAVATO®?
SPRAVATO® is the brand name for esketamine, a prescription nasal spray used to treat certain depressive disorders in adults.
Unlike traditional antidepressants that primarily act on serotonin, norepinephrine, or dopamine, esketamine acts primarily through the brain's glutamate system.
SPRAVATO® is administered in a certified healthcare setting under the supervision of a healthcare provider. Patients remain at the healthcare setting for monitoring for at least two hours after each treatment.
This is not a medication you take home.
UNDERSTANDING YOUR OPTIONS
SPRAVATO® and Ketamine Are Related —
But They Aren't the Same Treatment.
SPRAVATO®
A prescription nasal spray administered by the patient under healthcare-provider supervision in a certified treatment setting.
SPRAVATO® has FDA-approved indications for certain depressive disorders.
Treatment follows specific administration, monitoring, and safety requirements through the SPRAVATO® REMS program.
Ketamine
Administered intravenously in a medically supervised setting.
Ketamine is FDA-approved as an anesthetic; its use for psychiatric conditions such as depression is considered off-label.
Treatment protocols are individualized according to clinical evaluation and response.
TREATMENT ELIGIBILITY
Who May Be a Candidate for SPRAVATO®?
SPRAVATO® is not appropriate for everyone.
Eligibility depends on the specific depressive condition being treated, previous treatment history, current medications, medical history, and other individual factors.
At Z&Z Wellness, Zahida evaluates these factors before determining whether SPRAVATO® may be an appropriate treatment option.
Your consultation is also an opportunity to discuss other available options if SPRAVATO® isn't the right fit.
YOUR TREATMENT EXPERIENCE
What to Expect With SPRAVATO®
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Your care begins with an evaluation of your symptoms, diagnosis, medical history, medications, previous treatments, and goals.
Zahida will determine whether SPRAVATO® may be clinically appropriate and discuss what treatment would involve.
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If SPRAVATO® is recommended, insurance benefits and any required authorization will need to be addressed before treatment begins.
Coverage varies by insurance plan and individual eligibility.
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SPRAVATO® is a nasal spray that you administer yourself while under the supervision of a healthcare provider in the certified treatment setting.
It cannot be taken home for administration.
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After administration, you remain at the clinic for at least two hours of monitoring.
During this time, appropriate vital signs and your response to treatment are monitored. The REMS specifically requires monitoring for issues including sedation, dissociation, respiratory depression, and changes in vital signs.
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You will need to make arrangements to leave the healthcare setting safely after treatment and follow the activity restrictions provided to you.
You'll receive specific instructions before beginning treatment so you know what to plan for.
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SPRAVATO® is administered according to an established treatment schedule, with treatment frequency changing over time when clinically appropriate.
Zahida will monitor your response and determine ongoing recommendations based on your individual treatment plan.
SAFETY + OVERSIGHT
Why Does SPRAVATO® Require In-Clinic Monitoring?
SPRAVATO® is available through a restricted safety program called the SPRAVATO® Risk Evaluation and Mitigation Strategy (REMS).
The program establishes specific requirements for healthcare settings, patients, administration, and monitoring because of risks including sedation, dissociation, respiratory depression, and changes in vital signs.
For outpatient treatment, patients are enrolled in the REMS program, administration takes place under healthcare-provider supervision, and patients are monitored for at least two hours following each treatment.
This isn't simply an administrative requirement. It's part of the safety structure surrounding SPRAVATO® treatment.
Learn About the SPRAVATO® REMS Program
DURING TREATMENT
What Does SPRAVATO® Feel Like?
Experiences vary from person to person.
SPRAVATO® can cause temporary effects such as sedation and dissociation—a feeling of disconnection from yourself, your thoughts, or your surroundings. Changes in perception and other effects may also occur.
This is one reason patients remain in the treatment setting for observation following administration.
Zahida will explain what you may experience, what will be monitored, and when you are considered ready to leave before your first treatment.
UNDERSTANDING COVERAGE
Does Insurance Cover SPRAVATO®?
Unlike off-label IV ketamine treatment for mental health conditions, SPRAVATO® may be covered by insurance for eligible patients, subject to the requirements of the patient's specific plan.
Coverage may depend on factors such as:
Diagnosis
Previous medication trials
Medical necessity
Prior authorization
In-network benefits
Individual insurance requirements
Coverage is not guaranteed, and out-of-pocket responsibility varies by plan.
Contact Z&Z Wellness about SPRAVATO® →
PERSONALIZED CARE THROUGHOUT TREATMENT
More Than a Place to Receive Your Dose.
SPRAVATO® has a standardized safety process. Your care shouldn't feel standardized.
At Z&Z Wellness, Zahida considers your symptoms, health history, previous treatment experiences, medications, response to care, and goals throughout the treatment process.
Required monitoring is only one part of your experience. Understanding how you're doing— and what should happen next—is equally important.\
Individual Evaluation
Treatment begins with understanding whether SPRAVATO® is appropriate for you.
Medical Oversight
Your treatment and required observation occur in a medically supervised environment.
Ongoing Assessment
Your response helps inform recommendations as treatment progresses.
COMMON QUESTIONS
SPRAVATO® FAQ
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No. SPRAVATO® contains esketamine, which is related to ketamine but is a distinct medication. SPRAVATO® is administered as a nasal spray and has specific FDA-approved indications and REMS requirements.
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No. SPRAVATO® must be administered in a certified healthcare setting under healthcare-provider supervision and cannot be dispensed to the patient for home use.
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Patients must be monitored for at least two hours following administration. Your total appointment may be longer depending on preparation and your individual response.
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Common side effects can include dizziness, nausea, sedation, changes in perception or feelings of disconnection, and temporary increases in blood pressure. Because these effects can occur, SPRAVATO® is administered in a certified healthcare setting with monitoring after each treatment.
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You need to arrange to safely leave the healthcare setting after treatment and follow the post-treatment restrictions provided by your healthcare team.
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SPRAVATO® follows a structured treatment schedule that generally changes in frequency over time. Your exact treatment plan depends on the indication, response, and clinical recommendations.
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Many insurance plans may provide coverage for eligible patients, but requirements and patient responsibility vary. Prior authorization or documentation of previous treatment may be required.
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The appropriate option depends on your diagnosis, treatment history, medical considerations, insurance coverage, preferences, and clinical eligibility. Zahida can discuss the differences with you during your consultation.
A DIFFERENT OPTION FOR DEPRESSION
Could SPRAVATO® Be Right for You?
Complete a consultation request and Zahida will personally review your information, learn more about your treatment history, and help determine whether SPRAVATO® or another treatment option may be appropriate.